2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-132029
    Benzyl-PEG6-amine 86770-78-7
    Benzyl-PEG6-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyl-PEG6-amine
  • HY-141294
    PEG3-bis(phosphonic acid) 254762-10-2
    PEG3-bis(phosphonic acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    PEG3-bis(phosphonic acid)
  • HY-140276
    DBCO-NHCO-PEG13-NHS ester 2784618-59-1
    DBCO-NHCO-PEG13-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-NHCO-PEG13-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-NHCO-PEG13-NHS ester
  • HY-172125
    AMPRO-222
    AMPRO-222 is a PROTAC linker that can act as a linker of PROTAC PROTAC BRD4 Degrader-29 (HY-172124).
    AMPRO-222
  • HY-138479
    Benzyl-PEG2-ethanol 2055300-50-8
    Benzyl-PEG2-ethanol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyl-PEG2-ethanol
  • HY-140787
    Azide-PEG6-amido-C16-Boc
    Azide-PEG6-amido-C16-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. Azide-PEG6-amido-C16-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azide-PEG6-amido-C16-Boc
  • HY-140838
    Boc-NH-PEG6-azide 1292268-15-5
    Boc-NH-PEG6-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Boc-NH-PEG6-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Boc-NH-PEG6-azide
  • HY-140371
    Tos-PEG12-Tos 1456708-45-4
    Tos-PEG12-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Tos-PEG12-Tos
  • HY-116186
    m-PEG5-MS 130955-38-3
    m-PEG5-MS is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG5-MS is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    m-PEG5-MS
  • HY-141097
    Acid-PEG13-NHS ester 2152679-62-2
    Acid-PEG13-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Acid-PEG13-NHS ester
  • HY-138441
    Boc-NH-PEG11-NHS ester
    Boc-NH-PEG11-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-PEG11-NHS ester
  • HY-140789
    Azide-PEG9-amido-C8-Boc
    Azide-PEG9-amido-C8-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azide-PEG9-amido-C8-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azide-PEG9-amido-C8-Boc
  • HY-140561
    N-(Azido-PEG3)-N-Boc-PEG3-NHS ester 2112731-51-6
    N-(Azido-PEG3)-N-Boc-PEG3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Azido-PEG3)-N-Boc-PEG3-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-(Azido-PEG3)-N-Boc-PEG3-NHS ester
  • HY-140221
    Azido-PEG1-C2-methylamine 1835759-88-0
    Azido-PEG1-C2-methylamine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG1-C2-methylamine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG1-C2-methylamine
  • HY-W096156
    I-PEG6-OH 136399-07-0
    I-PEG6-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    I-PEG6-OH
  • HY-140966
    Mal-PEG12-Boc
    Mal-PEG12-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-PEG12-Boc
  • HY-176383
    PEG3-amide-C2-COOH
    PEG3-amide-C2-COOH is a PROTAC linker that can be used in the synthesis of PROTACs, such as BCL6 PROTAC 1 (HY-122829).
    PEG3-amide-C2-COOH
  • HY-141133
    Propargyl-PEG4-tetra-Ac-beta-D-glucose 1360446-31-6
    Propargyl-PEG4-tetra-Ac-beta-D-glucose is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Propargyl-PEG4-tetra-Ac-beta-D-glucose
  • HY-141055
    Cy5-PEG5-amine hydrochloride
    Cy5-PEG5-amine (hydrochloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Cy5-PEG5-amine hydrochloride
  • HY-130298
    Amino-PEG11-OH 15332-94-2
    Amino-PEG11-OH is non-cleavable 11 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-PEG11-OH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG11-OH
PROTAC Linkers Isoform Comparison

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